Copy Number Analysis Using a Higher Content Chromosomal Microarray with an Accelerated Workflow
Wednesday, November 15, 2023
1:00 PM – 1:50 PM MST
Chromosomal Microarray is currently the first-tier test for identifying genomic copy number variants. To increase the power and speed of CMA, we have developed a new array with significantly increased content and highly accelerated workflow. The CytoScan HD Accel microarray has high-density genome-wide coverage, including increased coverage across >5070 relevant genes. The novel Reference Model built from six unique pre and postnatal tissue types produces sensitive CNV detection with up to 25% maternal cell contamination, and trisomy detection with up to 30% contamination. The highly accelerated workflow enables processing 24 gDNAs to hybridization in just one day.