Status of the Use of Polygenic Scores for PGT

Session Description: Polygenic Risk Score (PRS) is the weighted sum of thousands or millions of alleles, resulting in a single score to give a certain prediction of a phenotype or trait of interest. The prediction ability of PRS to quantify genetic predisposition to a certain outcome varies depending on the outcome or the condition of interest. The clinical use, the prognostic information, prediction of response to treatment or screening interventions areal under study. The American College for Medical Genetics and Genomics recently came out with points to consider documents that address considerations associated with laboratory development of PRS, clinical implementation and genetic counseling resources. This session is aimed to increase awareness of clinical providers to various aspects of PRS testing, counseling before and after results, learn about the limitations, and where the current knowledge stands. Ethical considerations of PRS testing in embryo selection, and a discussion about points to consider in both the clinical and laboratory settings will be covered.