Medical Oncologist National Center For Tumor Diseases Heidelberg, Baden-Wurttemberg, Germany
Session Description: With the influx of data from next-generation sequencing, a systematic approach to interpreting and reporting sequence variants in cancer is crucial. The guidelines presented by the AMP working group has proposed a four-tiered system, based on clinical significance, for making these complex calls in somatic cancer. This session demonstrates the process of classification, interpretation and reporting of sequence variants in cancer. For functional classification of pathogenicity (oncogenicity), the of ClinGen/CGC/VICC process will be presented and discussed. For somatic variant interpretation and reporting, the AMP/ASCO/CAP and ESMO ESCAT frameworks and similar structures will be addressed.
If this session topic is of interest to you, please consider looking at the following courses on AMP EDucation (AMPED™ Online)
Title: AMP/ASCO/CAP Standards and Guidelines of Somatic Variant Interpretation and Reporting Click here to learn more.
Title: Assessments of Somatic Variant Classification Using the AMP/ASCO/CAP Guidelines Click here to learn more.
Learning Objectives:
Participants will be able to correctly classify pathogenicity of somatic variants in cancer
Participants will be able to successfully develop and implement an SOP for consistent and accurate classification of pathogenic somatic variants in cancer within their health system
Understand the progress made to date in shared variant databases and the importance of consistent variant calling within and between health systems
