Somatic Cancer Variant Curation Expert Panels (SC-VCEPs) and Their Pursuit of Oncogenicity Interpretations for SNVs and Fusions

Learning Objectives:

• Upon completion, participants will be able to understand how the CIViC platform facilitates expert crowdsourcing for cancer variant curation, including new interface features, variant significance curation, and community dissemination.
• Upon completion, participants will be able to discuss recent initiatives to enhance somatic cancer variant classifications, including the integration of curated interpretations into ClinVar and the potential role of artificial intelligence in automating curation.
• Upon completion, participants will be able to demonstrate proficiency in evaluating the clinical and oncogenic impact of SNVs and fusions, comprehend the crucial categories for assessing fusion oncogenicity, and appraise the relevance of functional data in determining clinical or oncogenetic significance.